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Engineered Heart Cells Conduct Electricity and Hope

June 20th, 2006 Justin Barad Cardiology, Genetics

Engineered tissue provides an electrical connection between the atria (not shown) and the ventricles (at left). Cardiac cells are shown in red and green, and the implanted cells in green.Researchers at Children’s Hospital Boston have made progress developing a tissue-engineering solution for children with complete heart block:

Patients with complete heart block, or disrupted electrical conduction in their hearts, are at risk for life-threatening rhythm disturbances and heart failure. The condition is currently treated by implanting a pacemaker in the patient’s chest or abdomen, but these devices often fail over time, particularly in infants and small children who must undergo many re-operations. Researchers at Children’s Hospital Boston have now taken preliminary steps toward using a patient’s own cells instead of a pacemaker, marking the first time tissue-engineering methods have been used to create electrically conductive tissue for the heart…
In complete heart block, electrical signals cannot pass from the heart’s upper chambers (atria) to the lower chambers (ventricles), leading to heart failure. In normal hearts, electrical impulses move first through the atria, then pause at the atrioventricular (AV) node. Then, after a short delay that allows the ventricles to fill with blood, the AV node releases the impulses, which move through the ventricles causing them to contract. In this way, the beats of the atria and ventricles are synchronized…
Collagen and myoblasts, cast into molds, create tissue strong enough to hold a suture. The cells align longitudinally, allowing surgeons to implant them in the desired orientation within the heart.Cowan’s team, including first author Yeong-Hoon Choi in Children’s Department of Cardiac Surgery, obtained skeletal muscle from rats and isolated muscle precursor cells called myoblasts. They “seeded” the myoblasts onto a flexible scaffolding material made of collagen, creating a 3-dimensional bit of living tissue that could be surgically implanted in the heart.
The cells distributed themselves evenly in the tissue and oriented themselves in the same direction. Tested in the laboratory, the engineered tissue started beating when stimulated electrically, and its muscle cells produced proteins called connexins that channel ions from cell to cell, connecting the cells electrically.
When the engineered tissue was implanted into rats, between the right atrium and right ventricle, the implanted cells integrated with the surrounding heart tissue and electrically coupled to neighboring heart cells. Optical mapping of the heart showed that in nearly a third of the hearts, the engineered tissue had established an electrical conduction pathway, which disappeared when the implants were destroyed. The implants remained functional through the animals’ lifespan (about 3 years).

It’s going to be a while before we see this device available clinically, but it’s an exciting example of just how powerful tissue engineering can be.
The press release at Children’s Hospital Boston…

Justin Barad

Justin Barad is a board eligible pediatric orthopaedic surgeon. He did his fellowship at Boston Children's Hospital in the Harvard Combined Orthopaedic Surgery program and his residency at UCLA. He is also the Founder and CEO of Osso VR, a clinically validated surgical simulation platform. His interests include Virtual/Augmented Reality, robotics, surgical navigation and 3D Printing/Scanning, He is always looking to discuss the latest and greatest in medtech. He has been writing for Medgadget about medical technology since 2006 and also has several research publications and presentations.

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