Vanderbilt University Medical Center is reporting that it is “one of 40 centers nationwide to enroll patients in a study to determine the efficacy and safety of a new pacing device [-ed.] for heart failure patients. This is the first time the device, called the Optimizer III, will be implanted in humans.”
The Optimizer™ System, manufactured by Impulse Dynamics N.V. is being investigated as a treatment for patients with moderate to severe heart failure. Essentially, the device is thought to provide intracardiac positive inotropic support. The company, headquartered in Curacao, provides the following info about the Cardiac Contractility Modulation (CCM) technology of this system:
Impulse Dynamics’ core technology involves the control of individual cell activity during a time period when the cell is already electrically active. The electrical signals applied from an electrode produce an immediate and powerful modulating effect on the normal function of the affected cells.
The therapy can be delivered with a high degree of specificity; delivering therapy directly to a specific location within the target organ ensures maximal response and enables control of the dose-response relationship. The therapy can be turned on and off at will.
Impulse Dynamics has achieved significant progress in the field of cardiology with the advancement of Cardiac Contractility Modulation (CCM). CCM is a unique method for treating the failing heart; nonstimulatory impulses are delivered during the absolute refractory period (ARP) and are intended to enhance contractility and overall cardiac performance…
Unlike a pacemaker, the CCM signals do not initiate a new heart beat. Rather, these signals are intended to enhance the strength of the heart. The ability of CCM signals to enhance heart strength is currently under investigation.
The Optimizer™ System consists of a programmable implantable pulse generator (IPG), a portable programmer, the Monita System, a charger and percutaneous pacemaker leads. The implantable pulse generator produces the CCM signals that are delivered to the heart through the pacemaker leads. The portable programmer allows medical personnel to customize the Optimizer signal parameters according to each patient’s needs. The charger permits the patient to recharge the battery of the Optimizer III in the comfort of their home.
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