One may recall that last year’s Nobel Prize in Medicine was awarded for the discovery of the infectious cause of peptic ulcer disease. Now scientists from the University of Wisconsin think they might have evidence of human adenovirus Ad-37 causing obesity in chickens. From the American Physiological Society’s press release about the study published in the January issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology:
“The prevalence of obesity has doubled in adults in the United States in the last 30 years and has tripled in children,” the study noted. “With the exception of infectious diseases, no other chronic disease in history has spread so rapidly, and the etiological factors producing this epidemic have not been clearly identified…”
“The nearly simultaneous increase in the prevalence of obesity in most countries of the world is difficult to explain by changes in food intake and exercise alone, and suggest that adenoviruses could have contributed,” the study said. “The role of adenoviruses in the worldwide epidemic of obesity is a critical question that demands additional research.”
The theory that viruses could play a part in obesity began a few decades ago when Nikhil Dhurandhar, now at Pennington Biomedical Research Center at LSU, noticed that chickens in India infected with the avian adenovirus SMAM-1 had significantly more fat than non-infected chickens. The discovery was intriguing because the explosion of human obesity, even in poor countries, has led to suspicions that overeating and lack of exercise weren’t the only culprits in the rapidly widening human girth. Since then, Ad-36 has been found to be more prevalent in obese humans.
In the current study, Whigham et al. attempted to determine which adenoviruses (in addition to Ad-36 and Ad-5) might be associated with obesity in chickens. The animals were separated into four groups and exposed to either Ad-2, Ad-31, or Ad-37. There was also a control group that was not exposed to any of the viruses. The researchers measured food intake and tracked weight over three weeks before ending the experiment and measuring the chickens’ visceral fat, total body fat, serum lipids, and viral antibodies.
Chickens inoculated with Ad-37 had much more visceral fat and body fat compared with the chickens infected with Ad-2, Ad-31 or the control group, even though they didn’t eat any more. The Ad-37 group was also generally heavier compared to the other three groups, but the difference wasn’t great enough to be significant by scientific standards.
The authors concluded that Ad-37 increases obesity in chickens, but Ad-2 and Ad-31 do not. “Ad-37 is the third human adenovirus to increase adiposity in animals, but not all adenoviruses produce obesity,” the study concluded.
What’s next? Vaccination against obesity?
The press release…