The Accordion Pill, a controlled release drug delivery system, is the creation of a Jerusalem-based startup Intec Pharma. Also known as Gastric-Retentive Dosage Form (GRDF) system, this regular looking pill opens like an accordion inside the stomach to slowly release a variety of drugs with different physical and pharmacological properties for prolonged periods of time:
Convenient Oral Delivery
The form is incorporated into a standard size gelatin capsule. After oral administration, the dosage is retained in the stomach, allowing it to receive constant exposure to the entire absorptive surface of the stomach and small intestine. At the absorption sites in the stomach, the duodenum or in the jejunum (small intestine), the drug is released in a slow, controlled manner, through a continuous infusion that optimizes absorption.
The Intec GRDF platform is composed of polymers that are listed within the IIG (inactive ingredients guide), or as GRAS (Generally Recognized As Safe) materials by the FDA.
Better compliance, more effective treatments
The GRDF enhances patient care by significantly improving compliance via less frequent dosing. Better bioavailability will deliver enhanced efficacy and reduce toxic side effects.
A Solution for a Broad Range of Drug Therapies
The GRDF platform is non-drug specific, which means it can serve as a platform to include large amounts of a variety of active agents and drugs with different physicochemical properties. To date, this has been proven on dosages of up to 350 mg in a single capsule. Because the active ingredients are released in a slow, controlled manner over an extended period of time, the pharmacology profile improves significantly.