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A Chip for a Neuron

March 30th, 2005 Medgadget Editors etc.

Rat neuron on electrolyte-oxide-silicon (EOS) field-effect transistor. (a) Electronmicrograph (colorized) of hippocampal neuron on silicon chip with linear array of p-type buried channel transistors after eight days in culture. Between source and drain leads are the open voltage-sensitive gates. The surface of the chip is chemically and structurally homogeneous consisting of silica with a surface profile below 20 nm. (b) Schematic cross section of a neuron on a buried-channel field-effect transistor with blow-up (drawn to scale) of the contact area. During an action potential, current flows through the adhering cell membrane and along the resistance of the cleft between chip and cell. The resulting extracellular voltage in the cleft modulates the source-drain current.The MIT Technology Review describes the research behind the first direct electrical interface between a semiconductor device and an individual mammalian nerve cell:

Context: The neurons of the mammal brain are hard to study, even when they’re isolated in the lab. For more than a decade, scientists have analyzed the large neurons of leeches and snails by linking them directly to silicon chips that record their electrical activity. But mammalian neurons are smaller, and though they can be grown on silicon, the resulting signals are typically too weak to yield useful data. The electrical activity of mammalian brain cells can be read with electrodes, but that can be imprecise and requires careful preparation steps.
Moritz Voelker and Peter Fromherz at the Max Planck Institute for Biochemistry have now designed the first computer chip that can record the firing of mammalian neurons, though so far only in a petri dish.
Methods and Results: As a neuron fires, the voltage across it changes, so a neuron on a chip affects how transistors underneath it conduct electricity. But in chips with conventional transistor designs, there’s so much naturally occurring noise that it swamps neural signals. So Voelker and Fromherz changed the geometry of the transistors to suit the electrical properties of living neurons. They buried the conducting channels of their transistors a few nanometers deeper than usual, making the transistor more sensitive to the low voltages and firing speeds of neurons. The transistors could detect the signal of an ?individual rat neuron in a group, without the elaborate sample preparation that ?conventional electrodes require. What’s more, the tran?sistors are significantly smaller than individual neurons and could in principle provide information on how subsections of a neuron behave.

The abstract at the Max Planck Institute for Biochemistry …
Flash: BrainGate Neural Interface System…

Medgadget Editors

Medical technologies transform the world! Join us and see the progress in real time. At Medgadget, we report the latest technology news, interview leaders in the field, and file dispatches from medical events around the world since 2004.

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