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Eyevensys, a clinical-stage biotechnology company based in France, has developed a method to perform non-viral gene therapy in the eye, with the aim of treating ocular diseases. The system uses ocular electrotransfection to deliver therapeutic genes into the eye. Consisting of an ocular device and an electrical pulse generator, the system can deliver DNA plasmids into the ciliary muscle. The idea is that the transfected cells in the eye allow for sustained local production of therapeutic proteins, which can then produce effects in a variety of structures in the eye,...

November 12th, 2019 by Medgadget Editors
Pain Management
Nevro, a firm based in Silicon Valley, won FDA approval for its Senza Omnia spinal cord neurostimulation system for chronic pain management. The device can deliver traditional spinal cord stimulation at frequencies below 1.5 kHz, along with Nevro's proprietary HF10 stimulation that goes up to 10 kHz. Both low and high frequency therapies can even be provided at the same time. The Senza Omnia can operate at frequencies between 2 and 10,000 Hertz, a range unheard of in a spinal cord stimulator. It is a rechargeable device and is guaranteed...Read More

November 12th, 2019 by Medgadget Editors
Rehab
Transcutaneous electrical muscle stimulation is used in a variety of clinical applications, including as a rehabilitation tool to help people with limited mobility. It is effective for maladies such as certain types of urinary incontinence, for example, but getting the muscles of the arm to move in unison and with appropriate strength via electrical stimulation through the skin is very difficult. Researchers at The Feinstein Institutes for Medical Research, a part of Northwell Health, a New York State healthcare network, have now developed a system that can, without relying on...Read More

November 12th, 2019 by Conn Hastings
Neurology
Researchers at the University of Wisconsin-Madison have developed an injectable flexible electrode that can aid in neuromodulation therapy, potentially replacing more rigid electrodes that do not mesh well with soft tissues. The injectable material consists of a silicone gel and small metal particles, and it forms a flexible bolus when injected around a target nerve. The nerve can then be electrically stimulated from the surface of the skin using a basic transcutaneous electrical nerve stimulation (TENS) unit. The approach could pave the way for effective neuromodulation therapy for a large...Read More

November 11th, 2019 by Medgadget Editors
Diagnostics
Affinity-based sensors are electrochemical devices that can detect a large variety of disease biomarkers. They typically have enzyme-coated electrodes onto which chemical biomarkers can stick, in the process changing the electrical characteristics of the device, something that can be accurately measured. Although they're extremely sensitive, when used in practice with whole blood, they quickly become fouled by all sort of compounds. This causes them to quickly lose their effectiveness, making affinity-based electrochemical detection impractical until now. That is because researchers at Harvard's Wyss Institute have now developed a way to...Read More

November 11th, 2019 by Medgadget Editors
Materials
Stem cells hold a great deal of promise in treating a huge variety of human diseases. Although much hyped to the general public some years ago, it turned out to be very difficult to safely use stem cells to generate replacement tissues without inadvertently introducing tumors or other maladies. Knowing how stem cells differentiate, and whether they turn into healthy cells, is key to overcoming a major hurdle for stem cell therapies. Now, a team at Rutgers University has developed a platform and accompanying imaging technology that can accurately monitor...Read More

November 11th, 2019 by Conn Hastings
Diagnostics
Researchers at Lawrence Berkeley National Laboratory have developed synthetic peptide-coated magnetic beads that can be used to detect the presence of misfolded proteins in blood samples. Misfolded proteins are a factor in a number of diseases, including prion diseases, Alzheimer’s, and Parkinson’s. To date it has been difficult to detect such proteins in patient blood samples, often because they are present in very small quantities and closely resemble their correctly folded cousins. The new beads bind to specific misfolded proteins in blood samples, paving the way for rapid and convenient...Read More

November 8th, 2019 by Medgadget Editors
Pediatrics
While there are a number of drugs to treat Attention Deficit Hyperactivity Disorder (ADHD), they can have some pretty serious side effects. Researchers in Singapore at the country's Institute of Mental Health (IMH), Duke-NUS (National University of Singapore) Medical School, and A*STAR (Agency for Science, Technology and Research), have developed a system that combines neuromonitoring with video games to help kids improve their ADHD symptoms. Neeuro Pte Ltd. is a local company that has been spun off to commercialize the technology. So far, a randomized controlled trial of the prototype...Read More

November 8th, 2019 by Medgadget Editors
Neurology
As kids grow, their brains undergo a development process that is poorly understood. Children can have short attention spans, move around a lot, and are not easy to get into and then keep still inside a stationary scanner. Now, a collaboration of scientists from University of Nottingham, University of Oxford, and University College London has developed a functional magnetoencephalography scanner that young kids can wear while playing video games and doing other normal activities. Using the technology, it may be possible to better understand how a variety of brain conditions...Read More

November 7th, 2019 by Medgadget Editors
Neurology
Ischemic strokes can cause havoc in the brain, but early and properly directed treatment can mitigate a lot of damage. While there are a number of options to unclog blocked arteries, the potential to provide additional drug therapy remains mostly unexplored because of the difficulty in getting medications past the blood-brain barrier. Now, researchers at the University of Manchester are reporting that they were able to pass liposomes across the tiny tears in the vasculature that occur during ischemic strokes. Liposomes are lipid vesicles, naturally produced by the body and...Read More

November 7th, 2019 by Medgadget Editors
Cardiology
Philips is releasing a new vital signs monitor designed to offer advanced warning on worsening patient status within general care clinical environments. The EarlyVue VS30 is a newly FDA cleared device featuring Philips' Early Warning Scoring technology that spots tell-tale signs of degradation in patient health, and notifies clinicians sometimes even hours before the onset of symptomatic deterioration. The technology allows for earlier intervention and the prevention of serious events. Notifications and the information display can be set to match each patient's unique needs and the clinic can also adopt...Read More

November 6th, 2019 by Medgadget Editors
Neurology
Monitoring neurons and other excitable cells in vivo for research and clinical applications has usually required the use of electrode arrays. These are quite limited in their electrode density and the area that they can cover. Moreover, the amount of signal generated by the neurological system overwhelms any attempts at building large scale electronic microelectrode arrays. Fluorescent probes are another modality, but they come with a host of limitations and incompatibilities for use on living humans. This false-color scanning electron micrograph shows cardiomyocytes (colored in purple) cultured on an electro-plasmonic...Read More

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Medicine

Injectable Electrodes for Neuromodulation

Researchers at the University of Wisconsin-Madison have developed an injectable flexible electrode that can aid in neuromodulation therapy, potentially replacing... November 12th, 2019

Cardiology

Injectable Electrodes for Neuromodulation

Researchers at the University of Wisconsin-Madison have developed an injectable flexible electrode that can aid in neuromodulation therapy, potentially replacing... November 12th, 2019

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