Scientists Tackle Quantum Mechanics to Improve MRI Sensitivity

For MRI, it is the interaction of the nuclei with the magnetic field that is key, as magnetic field strength varies with location, enabling a researcher to code different parts of the body with different frequencies. Through the measurement of the atomic precession frequencies, an MRI radiologist can reconstruct a two-dimensional or three-dimensional image that accurately depicts the interior of a patient's body.

In performing such measurements, scientists often need to invert the nuclei so they are aligned against the magnetic field. Inverting the nuclei of people inside MRI scanners can reveal such things as cancer tumors, whose slightly different interaction with the nuclear spins can be used to detect their presence amid surrounding healthy tissue.

This is where adiabatic processes come into play. The inversions are often done "adiabatically", by subjecting the target to low power radio waves that sweep through a specific range of frequencies. If the sweep is performed slowly enough, then all the nuclei will ultimately be inverted.

"The confounding thing", says Grandinetti, "is that for decades adiabatic sweeps worked in many situations, even though the theory predicted that they should not have. To be fair, it wasn't clear that this discrepancy posed a real problem, and most people thought the conventional theoretical approach was doing a fine job in guiding them towards the optimum adiabatic process. It was only after we fully understood the reason for the discrepancy that we realized the conventional theoretical approach contained a flaw that might prevent the optimum adiabatic process from being discovered".

In the recent paper, Grandinetti and his colleagues solve this long-standing puzzle by introducing the concept of super-adiabaticity into the problem. Super-adiabaticity was first described in 1987 by Sir Michael Berry, a mathematical physicist at University of Bristol. When applied to magnetic resonance, it uncovers hidden behavior in the nuclear inversions that researchers had previously considered unrelated to adiabaticity.

Grandinetti and his colleagues describe a mathematical algorithm that can be used to predict the previously mysterious paths that the nuclei took on their way to the proper target state. This revelation, and the mathematical algorithm for its discovery, are particularly exciting as they open the door to new approaches for designing adiabatic processes in magnetic resonance as well as in other related fields.

One example is in a search for an MRI technique that does not require a patient to enter the confines of a large tube. Researchers are trying to exploit the stray fields of large magnets to do MRI, where the magnetic field is not contained only in the interior of a contraption but is leaking to the outside. The field becomes weaker as one moves further away from the center of the magnet, but researchers have been working on exploiting this natural non-uniformity as an aid to observe internal structures in objects.

"The problem is that these stray fields are highly inhomogeneous in nature, and to make up for this deficiency, researchers must control the dance of the spins in a way that compensates for this," said Grandinetti. "And this is exactly where the more precise control of superadiabaticity may prove to be a revolution in MRI. Who knows--may be a few years from now, you will be casually sitting next to the intimidating device, without the need for sedation?"

Press release: Dancing Atoms Now Understood ...