Wednesday, March 12, 2008

Free Radical Enzymatic Device (FRED): We Definitely Are Not Ready

Filed under: OTC

Pulse Health, a Portland, OR company, has secured $2.15M in Series A financing to further develop and market its line of products that "target the antioxidant supplement channel." In case you don't know what the antioxidant supplement channel is, neither do we. (And, you know, we have a pretty diverse group of people around here: some are still in medical school, others in residency, and others are in practice.) To make us more flabbergasted , the company's "flagship" product is a noninvasive breath test device that supposedly "detects free radicals through a colorimetric reaction", and spews out a "free radical level baseline 'number.'"

Now comes the real fluff from the company:

The FRED System allows consumers to measure their metabolic baseline and guide them in a scientifically grounded health and wellness program. FRED tests will be able to help identify the effects of diet, stress, supplements, and everyday living based on free radical levels in individuals. Once armed with this critical information, consumers can create optimal, enhanced lifestyle programs built around stress-reduction techniques like a healthy diet, regular exercise and supplementation.

Are you a skeptic like we are? What do you think?

Product page: FRED...

Press release: Pulse Health Successfully Closes Series "A" Round...

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replies: 4 comments
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The "antioxidant supplement channel" isn't a science phrase, it's a marketer phrase! They mean the industry that sells antioxidant dietary supplements to consumers. That would include vitamins, certain herbs, and certain other nutrients. Beyond that, the product is baffling but I suspect the consumer would buy the gadget and then a company would tell them to buy a lot of dietary supplements.
PS I am a premed. Do I win a cookie?


Posted by: Sarah
on March 12, 2008 11:48 AM GMT

I assume this is a hydrogen peroxide reaction in exhaled breath condensate. The detection limit for this type of a thing is in the 10nM range (Respir Med. 2002 Mar;96(3):197-203.). Sounds pretty useless if all it's going to do is convince people to get outside and play, don't eat all those cookies, and drink your orange juice (as if you needed a little device to tell you what your grandmother told you was good for you).


Posted by: Alec Sheehy
on March 12, 2008 12:04 PM GMT

Sounds like it's time for another round of Pseudoscience Friday!


Posted by: Bob J.
on March 12, 2008 04:30 PM GMT

Actually, some objective information about ongoing oxidation processes in the body may put some science behind the use of anti-oxidants. Plus it may help figure out which patients with asthma or COPD or diabetes have an inability to deal with teh oxidant loads, so that such patients can be selected for trials of anti-oxidants. Right now, doctors rely on an "evidence-base" that is itself based on poor thinking. For example, if anti-oxidants don't work in "asthma", perhaps that is because only SOME asthmatics have a problem dealing with oxidants. Find those individual patients (with a device like FRED) and try a study of antioxidants in them. That would be an intelligent study, although probably expensive.

I am all in favor of efforts to quantitate oxidation in the body. Excessive oxidation is tissue injury, which requires repair, which increases scarring. Aging...... Seems like a smart idea to me. But then, I am just a stupid academic physician/scientist. What do I know?


Posted by: JF
on April 30, 2009 07:11 AM GMT

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