Thursday, March 16, 2006

Ambien: Not Entirely Alseep...

Filed under: Neurology

blame it on the ambien
Working with shift-changing ER docs as we do, we hear a lot of talk about Ambien (zolpidem), Sanofi's popular sleep aid. But none of our colleagues have mentioned this bizarre adverse effect: wakeful behavior and amnesia:

"I would wake up in the morning and there would be candy wrappers all around the bed," she says. "There would be crumbs in the bed. There would be all kinds of evidence that someone had been eating in the bed. But I had absolutely no recollection of it."

Her sons stayed up to watch her, afraid she would injure herself.

"We have had people, infrequently, cut themselves as they're trying to chop up food to eat in the middle of the night," notes Mahowold.

...Mahowald points out that, "Sleep and wakefulness can occur simultaneously. Everybody thinks the brain is either all awake or all asleep, and that's not true. The brain can be literally half awake and half asleep."


Interns would agree: you don't need Ambien to put yourself in this state -- just 30 consecutive hours of patient care. But the makers of Ambien wish to inform the public that this side effect is rare -- fewer than 1000 logged cases, in over 100 million prescriptions over the years.

More from Sanofi and Wikipedia...

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replies: 5 comments
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I can attest to this side-effect. Since I've been on Ambien, many mornings I have gone into the kitchen, only to find bowls in the sink that had held food the night before, and food wrappers in the trash. I have absolutely no remembrance of having eaten anything. I have also sent e-mails I don't remember sending (the only way I know I sent them is to see the replies the next day) and had conversations that I don't remember having, etc. From others I have talked to, things like this, especially the eating, happen all the time. It's totally bizarre, but true. I think that the company needs to stop saying this is extremely rare and be more truthful about the amnesia and sleepwalking.


Posted by: anonymous
on March 16, 2006 10:01 PM GMT

Not that rare........ My wife takes 20mg of Ambien nearly every night. I work nights. She will often call me while I am at work to have me pick certain "junk" foods up from the convenience store, and usually has no memory of it. On many occasions I have observed her get out of bed, go down to the kitchen, and return with the most unhealthy foods. I have even found the gas stove on in the middle of the night.
She has made phone calls she does not remember. Made purchases online she did not know of till it showed up on the bank balance. Had sex and not remembered it. (as much as it hurts to type that) Talks in her sleep, nearly fallen down a flight of steps on several occasions.
I have seen first hand; the "drunken stupor" created by Ambien.
I know of 3 people in the past 10 years that have taken this and ALL have had the same side effects.
This is NOT a rare thing. The drug company is trying to brush this under the rug.
Any medication that causes amnesia is a problem. I find it very hard to believe that only 1000 people have had this side effect. The key word is "logged" cases. Not actual. Hey big drug companies.... I bet if you did an actual survey with 1000 of the people that currently take this drug, you would get a much different result.
Interview spouces and significant others. (the patient won't remember)


Posted by: Rob P
on March 17, 2006 01:40 AM GMT

This weird behavior is not rare. Once taking the medication, I slept walked in to the kitchen, slapped a TV dinner iin to microwave, (wih too much time on the clock) and then just went back to bed. Only to find a burnt up TV Dinner and a burnt up Microware in the morning. Other times, you can sleep through alarm clocks. But once I woke up to find that the dresser had been pulled off the wall and the clock entirely un plugged. I had ready felt shame about this behavior and never really talked about it, but its good to see people "comming out of the closet with it" as driving, cooking, rearanging furniture and organizing bookshelves is wierd. There where probaly other things I did, but don't even have a clue as to remember them.


Posted by: Steve
on April 23, 2006 03:17 PM GMT

Lastnight's 10 mg of Ambien yielded:
One bowl of leftover shrimp stir fry at one a.m. and a humiliating email sent to my ex boyfriend who I wish wasn't my ex boyfriend! The only benefit being my dog got to lick the shrimp bowl and eight wonderful hours of sleep. This drug is dangerous though! I caution any and all who have things left unsaid to put the Ambien in your mouth and make certain your computer and phones are off!!! Your inhibitions are shed just as soon as the stuff hits your bloodstream! Lock up the fridge, hide your keys and hit the bed with a good book. Otherwise, be prepared to do some apologizing the next day to others and yourself!


Posted by: Sidney
on September 10, 2006 07:17 PM GMT

My mother took Ambien for a week. She would call me in the middle of the nite and say things like don't forget the baby he needs to bake with the beans, or talk to the dog and try to put makeup it so it can go fishing, even had conversations with the devil. We've found her sitting on the toilet in the dark, walking around in circles like a zombie. so forgive me when I say this but the company better retest there product. because its aweful. My sister tried it once and her husband had to stop her from getting naked and running out side she said she was going skiing. my neighbor (a firefighter) new a fellow firefighter who almost got shot by the polce because he was outside his house naked with a gun. this drug really makes you crazy.


Posted by: a daughter
on November 28, 2006 09:54 PM GMT