Monday, March 21, 2005

Affinergy's Site-Specific Biological Delivery System

Filed under: etc.

Affinergy, Inc., a spinoff from Duke University, was awarded by Frost & Sullivan the 2005 Technology Innovation of the Year Award for medical coatings/biocoatings technologies.

Company describes its technology:

Affinergy's site-specific biological delivery technology is called "Interfacial Biomaterials" ("IFBM"). IFBMs are modular structures that include two functional peptides:

-- one designed to selectively bind to a specific biological material

-- one designed to selectively bind to a specific target surface (biological or synthetic)

The two peptides are joined through a proprietary linker technology that offers unique capabilities such as cleavability or cross-linking. Affinergy is building and patenting a "library" of peptides that bind with high affinity and high selectivity to bioactive and synthetic materials that are widely used in the biomedical and therapeutic industries.

Affinergy's Discovery Platform contains billions of proprietary peptides that can be efficiently screened for binding capabilities. We typically find a range of peptides with variable affinities to the target which allows us to engineer a controlled release curve to fit the optimal conditions of the therapeutic or device. Moreover, we find binders that are highly selective and binders that cross react for a select group of materials. Affinergy's team has already identified binders to:

Biologics:

- Growth Factors
- Cell Receptors
- Cell Matrix Proteins, Collagen
- Enzymes, Antibodies

Biomedical Surfaces

- Titanium, Stainless Steel
- Teflon, PET, PETG, PGA
- Polystyrene, Polycarbonate
- Glass, Nylon, Latex

More at Affinergy...

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